5/16/2025
Last update
5/16/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.9
USERS' SCORE
Good
Based on 8 Reviews
8.1
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol)
125 mcg
625%
Top Medical Research Studies
9
We set out to explore how vitamin D impacts the formation of foam cells from vascular smooth muscle cells (VSMCs), which are key players in the development of atherosclerosis. Our investigation centered on whether vitamin D could suppress the creation of these foam cells and the potential involvement of a receptor called Toll-like receptor 4 (TLR4) in this process.
Using ApoE-/- mice, we assessed the effects of vitamin D supplementation on atherosclerotic plaque formation and looked at the expression of important genes related to cholesterol transport and TLR4. The results were promising—supplemental vitamin D significantly reduced the formation of foam cells and atherosclerotic plaques in the aorta. We noticed that vitamin D not only decreased the expression of TLR4 and other foam cell markers but also encouraged the upregulation of cholesterol transport proteins that help maintain healthy cell function.
In laboratory conditions, vitamin D proved effective in reducing the uptake of oxidized LDL by VSMCs while enhancing the efflux of cholesterol. Notably, we discovered that knocking down TLR4 impaired foam cell formation, suggesting its critical role in this process.
Overall, our findings highlight that vitamin D might be a protective agent against cardiovascular disease by reducing foam cell formation through the JNK-TLR4 signaling pathway. This suggests a potential avenue for dealing with atherosclerotic disease through vitamin D treatment.
Using ApoE-/- mice, we assessed the effects of vitamin D supplementation on atherosclerotic plaque formation and looked at the expression of important genes related to cholesterol transport and TLR4. The results were promising—supplemental vitamin D significantly reduced the formation of foam cells and atherosclerotic plaques in the aorta. We noticed that vitamin D not only decreased the expression of TLR4 and other foam cell markers but also encouraged the upregulation of cholesterol transport proteins that help maintain healthy cell function.
In laboratory conditions, vitamin D proved effective in reducing the uptake of oxidized LDL by VSMCs while enhancing the efflux of cholesterol. Notably, we discovered that knocking down TLR4 impaired foam cell formation, suggesting its critical role in this process.
Overall, our findings highlight that vitamin D might be a protective agent against cardiovascular disease by reducing foam cell formation through the JNK-TLR4 signaling pathway. This suggests a potential avenue for dealing with atherosclerotic disease through vitamin D treatment.
Read More
8
Vitamin D's role in heart health
We explored the relationship between serum vitamin D levels and the risk of cardiovascular disease, as well as all-cause and cancer mortality. Using data from over 11,500 adults aged 40 and older, we wanted to understand whether having higher amounts of this nutrient in our blood could lead to better health outcomes.
Our investigation focused on seeing if the connections between vitamin D and mortality were influenced by inflammation in the body. What we found was intriguing: higher serum levels of vitamin D were linked to lower risks of dying from heart disease and other causes, suggesting that maintaining sufficient vitamin D could be beneficial for heart health.
Additionally, we observed that these benefits might be partly due to reduced inflammation, as measured by biomarkers like C-reactive protein and white blood cell counts. This points to a promising area of research where vitamin D not only plays a role in overall health but could also reduce inflammation, which is a key player in cardiovascular conditions.
Our investigation focused on seeing if the connections between vitamin D and mortality were influenced by inflammation in the body. What we found was intriguing: higher serum levels of vitamin D were linked to lower risks of dying from heart disease and other causes, suggesting that maintaining sufficient vitamin D could be beneficial for heart health.
Additionally, we observed that these benefits might be partly due to reduced inflammation, as measured by biomarkers like C-reactive protein and white blood cell counts. This points to a promising area of research where vitamin D not only plays a role in overall health but could also reduce inflammation, which is a key player in cardiovascular conditions.
Read More
8
We wanted to understand how vitamin D levels affect cardiovascular health, specifically among individuals with type 2 diabetes. Our study involved 1,378 hospitalized patients, examining their vitamin D status and its relationship with cardiovascular disease (CVD).
We found that patients with lower levels of vitamin D were more likely to experience CVD. The research revealed that those deficient in vitamin D had a 1.25 times greater risk of heart disease compared to those with sufficient vitamin D levels. This relationship was particularly strong among women, older adults, and individuals dealing with obesity.
Additionally, we observed significant links between vitamin D deficiency and various cardiometabolic risk factors, including overweight/obesity, high blood pressure, and unhealthy lipid levels. This highlights the potential role of vitamin D in managing heart health, especially for those living with diabetes.
We found that patients with lower levels of vitamin D were more likely to experience CVD. The research revealed that those deficient in vitamin D had a 1.25 times greater risk of heart disease compared to those with sufficient vitamin D levels. This relationship was particularly strong among women, older adults, and individuals dealing with obesity.
Additionally, we observed significant links between vitamin D deficiency and various cardiometabolic risk factors, including overweight/obesity, high blood pressure, and unhealthy lipid levels. This highlights the potential role of vitamin D in managing heart health, especially for those living with diabetes.
Read More
Most Useful Reviews
8
Health improvement
4 people found this helpful
Great Vitamin D with an effective dosage! My vitamin D levels have risen significantly. I take it along with vitamin K2 and calcium. Since starting this regimen, I've noticed fewer illnesses, which is crucial for my autoimmune condition. The jar also has a lovely design!
Read More
9
Well tolerated
2 people found this helpful
This vitamin D is well tolerated, even for my sensitive stomach. A daily dose of 5,000 IU is effective for those with D3 deficiency and can assist in treating cardiovascular disease.
Read More
6
Reduced infections
2 people found this helpful
I used to suffer from sinusitis and frequent infections. After starting with Vigantol and then switching to this vitamin D3, my symptoms improved. After 8 months, I had a health check and my levels were at 46, suggesting it works for me. Moreover, the frequency of infections and colds has decreased, supporting my treatment for cardiovascular disease. I recommend it.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.9
- All Researches
9
We set out to explore how vitamin D impacts the formation of foam cells from vascular smooth muscle cells (VSMCs), which are key players in the development of atherosclerosis. Our investigation centered on whether vitamin D could suppress the creation of these foam cells and the potential involvement of a receptor called Toll-like receptor 4 (TLR4) in this process.
Using ApoE-/- mice, we assessed the effects of vitamin D supplementation on atherosclerotic plaque formation and looked at the expression of important genes related to cholesterol transport and TLR4. The results were promising—supplemental vitamin D significantly reduced the formation of foam cells and atherosclerotic plaques in the aorta. We noticed that vitamin D not only decreased the expression of TLR4 and other foam cell markers but also encouraged the upregulation of cholesterol transport proteins that help maintain healthy cell function.
In laboratory conditions, vitamin D proved effective in reducing the uptake of oxidized LDL by VSMCs while enhancing the efflux of cholesterol. Notably, we discovered that knocking down TLR4 impaired foam cell formation, suggesting its critical role in this process.
Overall, our findings highlight that vitamin D might be a protective agent against cardiovascular disease by reducing foam cell formation through the JNK-TLR4 signaling pathway. This suggests a potential avenue for dealing with atherosclerotic disease through vitamin D treatment.
Using ApoE-/- mice, we assessed the effects of vitamin D supplementation on atherosclerotic plaque formation and looked at the expression of important genes related to cholesterol transport and TLR4. The results were promising—supplemental vitamin D significantly reduced the formation of foam cells and atherosclerotic plaques in the aorta. We noticed that vitamin D not only decreased the expression of TLR4 and other foam cell markers but also encouraged the upregulation of cholesterol transport proteins that help maintain healthy cell function.
In laboratory conditions, vitamin D proved effective in reducing the uptake of oxidized LDL by VSMCs while enhancing the efflux of cholesterol. Notably, we discovered that knocking down TLR4 impaired foam cell formation, suggesting its critical role in this process.
Overall, our findings highlight that vitamin D might be a protective agent against cardiovascular disease by reducing foam cell formation through the JNK-TLR4 signaling pathway. This suggests a potential avenue for dealing with atherosclerotic disease through vitamin D treatment.
Read More
8
Our study delved into the potential benefits of vitamin D3 in improving cardiovascular health, particularly among hypertensive patients suffering from obesity and obstructive sleep apnea (OSA). We designed a randomized clinical trial where participants received either dapagliflozin (an SGLT-2 inhibitor), vitamin D3, a combination of both, or no treatment over a period of 16 weeks.
We evaluated various health parameters including weight, blood pressure, blood sugar levels, and heart function, and analyzed their impact on participants' quality of life. Interestingly, our results indicated that when vitamin D3 was combined with SGLT2 inhibitors, there were notable improvements in several cardio-metabolic outcomes and quality of life measures.
This finding suggests that the dual approach could be a promising strategy in managing cardiovascular risks associated with obesity and OSA. Though our study does not isolate the effects of vitamin D3 alone on cardiovascular disease, it highlights its potential role when paired with other treatments, offering a glimmer of hope for patients dealing with these health challenges.
We evaluated various health parameters including weight, blood pressure, blood sugar levels, and heart function, and analyzed their impact on participants' quality of life. Interestingly, our results indicated that when vitamin D3 was combined with SGLT2 inhibitors, there were notable improvements in several cardio-metabolic outcomes and quality of life measures.
This finding suggests that the dual approach could be a promising strategy in managing cardiovascular risks associated with obesity and OSA. Though our study does not isolate the effects of vitamin D3 alone on cardiovascular disease, it highlights its potential role when paired with other treatments, offering a glimmer of hope for patients dealing with these health challenges.
Read More
8
Vitamin D benefits blood pressure management
We examined the role of vitamin D supplementation in managing hypertension, particularly its effects on cardiovascular health. After analyzing data from a systematic review and meta-analysis that included 24 relevant studies, we discovered that vitamin D has significant benefits for blood pressure.
The findings revealed that vitamin D supplementation was linked to a notable reduction in both systolic and diastolic blood pressure. Specifically, vitamin D led to a decrease in systolic blood pressure by an average of 2.83 mmHg and diastolic blood pressure by 1.64 mmHg. This is promising news for those looking to manage hypertension more effectively.
Unlike calcium and magnesium, which only significantly lowered diastolic blood pressure but didn't impact systolic blood pressure or pulse rate, vitamin D showed consistent and significantly positive outcomes. Therefore, incorporating vitamin D into treatment plans for hypertensive patients could be a beneficial step toward improving cardiovascular health.
The findings revealed that vitamin D supplementation was linked to a notable reduction in both systolic and diastolic blood pressure. Specifically, vitamin D led to a decrease in systolic blood pressure by an average of 2.83 mmHg and diastolic blood pressure by 1.64 mmHg. This is promising news for those looking to manage hypertension more effectively.
Unlike calcium and magnesium, which only significantly lowered diastolic blood pressure but didn't impact systolic blood pressure or pulse rate, vitamin D showed consistent and significantly positive outcomes. Therefore, incorporating vitamin D into treatment plans for hypertensive patients could be a beneficial step toward improving cardiovascular health.
Read More
8
Vitamin D's role in heart health
We explored the relationship between serum vitamin D levels and the risk of cardiovascular disease, as well as all-cause and cancer mortality. Using data from over 11,500 adults aged 40 and older, we wanted to understand whether having higher amounts of this nutrient in our blood could lead to better health outcomes.
Our investigation focused on seeing if the connections between vitamin D and mortality were influenced by inflammation in the body. What we found was intriguing: higher serum levels of vitamin D were linked to lower risks of dying from heart disease and other causes, suggesting that maintaining sufficient vitamin D could be beneficial for heart health.
Additionally, we observed that these benefits might be partly due to reduced inflammation, as measured by biomarkers like C-reactive protein and white blood cell counts. This points to a promising area of research where vitamin D not only plays a role in overall health but could also reduce inflammation, which is a key player in cardiovascular conditions.
Our investigation focused on seeing if the connections between vitamin D and mortality were influenced by inflammation in the body. What we found was intriguing: higher serum levels of vitamin D were linked to lower risks of dying from heart disease and other causes, suggesting that maintaining sufficient vitamin D could be beneficial for heart health.
Additionally, we observed that these benefits might be partly due to reduced inflammation, as measured by biomarkers like C-reactive protein and white blood cell counts. This points to a promising area of research where vitamin D not only plays a role in overall health but could also reduce inflammation, which is a key player in cardiovascular conditions.
Read More
8
We wanted to understand how vitamin D levels affect cardiovascular health, specifically among individuals with type 2 diabetes. Our study involved 1,378 hospitalized patients, examining their vitamin D status and its relationship with cardiovascular disease (CVD).
We found that patients with lower levels of vitamin D were more likely to experience CVD. The research revealed that those deficient in vitamin D had a 1.25 times greater risk of heart disease compared to those with sufficient vitamin D levels. This relationship was particularly strong among women, older adults, and individuals dealing with obesity.
Additionally, we observed significant links between vitamin D deficiency and various cardiometabolic risk factors, including overweight/obesity, high blood pressure, and unhealthy lipid levels. This highlights the potential role of vitamin D in managing heart health, especially for those living with diabetes.
We found that patients with lower levels of vitamin D were more likely to experience CVD. The research revealed that those deficient in vitamin D had a 1.25 times greater risk of heart disease compared to those with sufficient vitamin D levels. This relationship was particularly strong among women, older adults, and individuals dealing with obesity.
Additionally, we observed significant links between vitamin D deficiency and various cardiometabolic risk factors, including overweight/obesity, high blood pressure, and unhealthy lipid levels. This highlights the potential role of vitamin D in managing heart health, especially for those living with diabetes.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
8
Health improvement
4 people found this helpful
Great Vitamin D with an effective dosage! My vitamin D levels have risen significantly. I take it along with vitamin K2 and calcium. Since starting this regimen, I've noticed fewer illnesses, which is crucial for my autoimmune condition. The jar also has a lovely design!
Read More
9
Well tolerated
2 people found this helpful
This vitamin D is well tolerated, even for my sensitive stomach. A daily dose of 5,000 IU is effective for those with D3 deficiency and can assist in treating cardiovascular disease.
Read More
6
Reduced infections
2 people found this helpful
I used to suffer from sinusitis and frequent infections. After starting with Vigantol and then switching to this vitamin D3, my symptoms improved. After 8 months, I had a health check and my levels were at 46, suggesting it works for me. Moreover, the frequency of infections and colds has decreased, supporting my treatment for cardiovascular disease. I recommend it.
Read More
9
Overall wellness
1 people found this helpful
I've been taking this vitamin for over a year, and it has significantly improved my levels and overall well-being. I also buy it for my parents, and they've noticed health improvements too.
Read More
7.5
Inflammation relief
1 people found this helpful
I take this vitamin for knee pain, and it's comparable to anti-inflammatory medications. Vitamin D is crucial for combatting inflammation and supports immune function.
Read More
Frequently Asked Questions
6
Reduced infections
2 people found this helpful
I used to suffer from sinusitis and frequent infections. After starting with Vigantol and then switching to this vitamin D3, my symptoms improved. After 8 months, I had a health check and my levels were at 46, suggesting it works for me. Moreover, the frequency of infections and colds has decreased, supporting my treatment for cardiovascular disease. I recommend it.
9
Overall wellness
1 people found this helpful
I've been taking this vitamin for over a year, and it has significantly improved my levels and overall well-being. I also buy it for my parents, and they've noticed health improvements too.
9
Well tolerated
2 people found this helpful
This vitamin D is well tolerated, even for my sensitive stomach. A daily dose of 5,000 IU is effective for those with D3 deficiency and can assist in treating cardiovascular disease.
8
Health improvement
4 people found this helpful
Great Vitamin D with an effective dosage! My vitamin D levels have risen significantly. I take it along with vitamin K2 and calcium. Since starting this regimen, I've noticed fewer illnesses, which is crucial for my autoimmune condition. The jar also has a lovely design!
7.5
Inflammation relief
1 people found this helpful
I take this vitamin for knee pain, and it's comparable to anti-inflammatory medications. Vitamin D is crucial for combatting inflammation and supports immune function.
6
Cramps relief
Thanks to this vitamin, my muscle cramps have ceased. I emphasise testing levels beforehand due to the risks of overdose. Vitamin D plays a key role in fighting cardiovascular diseases.
7.5
Bone health
1 people found this helpful
Combining vitamin D with K2 is essential to prevent calcium deposits in blood vessels. This combination supports bone health and is beneficial for the cardiovascular system.
7
We examined how vitamin D levels, specifically 25-hydroxyvitamin D [25(OH)D], relate to the risk of cardiovascular disease and overall mortality in patients with gout. This study included data from 7,337 gout patients enrolled in the UK Biobank, following them for an average of 11.4 years. We looked closely at serum 25(OH)D measurements taken at the beginning of the study to draw connections between vitamin D levels and health outcomes.
Our findings suggested an interesting pattern. Patients with low 25(OH)D levels, specifically those below 45 nmol/L, had a higher risk of death from any cause compared to those with higher levels. In fact, those with levels of 45 nmol/L or more had about a 28% lower risk of dying from any cause. We also noted that increasing vitamin D levels above the deficiency threshold might help lower the risk of cardiovascular disease, with evidence suggesting that reaching at least 50 nmol/L is beneficial.
These results highlight the importance of maintaining adequate vitamin D levels for gout patients, as it appears to be linked to reduced mortality risk, particularly related to cardiovascular issues. This study adds to the growing conversation about vitamin D's role in heart health and suggest we may need to consider vitamin D supplementation in patient care strategies.
Our findings suggested an interesting pattern. Patients with low 25(OH)D levels, specifically those below 45 nmol/L, had a higher risk of death from any cause compared to those with higher levels. In fact, those with levels of 45 nmol/L or more had about a 28% lower risk of dying from any cause. We also noted that increasing vitamin D levels above the deficiency threshold might help lower the risk of cardiovascular disease, with evidence suggesting that reaching at least 50 nmol/L is beneficial.
These results highlight the importance of maintaining adequate vitamin D levels for gout patients, as it appears to be linked to reduced mortality risk, particularly related to cardiovascular issues. This study adds to the growing conversation about vitamin D's role in heart health and suggest we may need to consider vitamin D supplementation in patient care strategies.
8
Vitamin D benefits blood pressure management
We examined the role of vitamin D supplementation in managing hypertension, particularly its effects on cardiovascular health. After analyzing data from a systematic review and meta-analysis that included 24 relevant studies, we discovered that vitamin D has significant benefits for blood pressure.
The findings revealed that vitamin D supplementation was linked to a notable reduction in both systolic and diastolic blood pressure. Specifically, vitamin D led to a decrease in systolic blood pressure by an average of 2.83 mmHg and diastolic blood pressure by 1.64 mmHg. This is promising news for those looking to manage hypertension more effectively.
Unlike calcium and magnesium, which only significantly lowered diastolic blood pressure but didn't impact systolic blood pressure or pulse rate, vitamin D showed consistent and significantly positive outcomes. Therefore, incorporating vitamin D into treatment plans for hypertensive patients could be a beneficial step toward improving cardiovascular health.
The findings revealed that vitamin D supplementation was linked to a notable reduction in both systolic and diastolic blood pressure. Specifically, vitamin D led to a decrease in systolic blood pressure by an average of 2.83 mmHg and diastolic blood pressure by 1.64 mmHg. This is promising news for those looking to manage hypertension more effectively.
Unlike calcium and magnesium, which only significantly lowered diastolic blood pressure but didn't impact systolic blood pressure or pulse rate, vitamin D showed consistent and significantly positive outcomes. Therefore, incorporating vitamin D into treatment plans for hypertensive patients could be a beneficial step toward improving cardiovascular health.
7
We aimed to understand the connection between vitamin D levels and subclinical carotid disease, particularly in middle-aged individuals with hypertension. In our study involving 223 nondiabetic patients, we measured their vitamin D status alongside important markers of arterial health through high-resolution ultrasound.
Our findings revealed a significant relationship: patients with lower vitamin D levels tended to have greater carotid artery thickness and a higher occurrence of plaques, which are indicators of potential cardiovascular issues. This relationship persisted even after we accounted for factors like age and the duration of hypertension.
Specifically, we observed that deficiencies in vitamin D went hand in hand with increased stiffness in the arteries and lower elasticity. This suggests that maintaining adequate vitamin D levels may be crucial for heart health and could potentially help prevent severe cardiovascular complications in hypertensive patients.
In conclusion, our findings support the idea that low vitamin D could be a risk factor for subclinical carotid disease, highlighting the importance of monitoring vitamin levels in at-risk populations. Further research could help clarify the role of vitamin D in cardiovascular health and disease prevention.
Our findings revealed a significant relationship: patients with lower vitamin D levels tended to have greater carotid artery thickness and a higher occurrence of plaques, which are indicators of potential cardiovascular issues. This relationship persisted even after we accounted for factors like age and the duration of hypertension.
Specifically, we observed that deficiencies in vitamin D went hand in hand with increased stiffness in the arteries and lower elasticity. This suggests that maintaining adequate vitamin D levels may be crucial for heart health and could potentially help prevent severe cardiovascular complications in hypertensive patients.
In conclusion, our findings support the idea that low vitamin D could be a risk factor for subclinical carotid disease, highlighting the importance of monitoring vitamin levels in at-risk populations. Further research could help clarify the role of vitamin D in cardiovascular health and disease prevention.
8
Vitamin D improves heart disease factors
We conducted a double-blind, randomized clinical trial to see how treating vitamin D deficiency could influence heart health, particularly in patients with ischemic heart disease (IHD). In our study, 44 IHD patients aged 40 to 65 were treated with either vitamin D or a placebo to assess changes in their lipid profiles and C-reactive protein (CRP) levels.
Our findings revealed that participants who received vitamin D supplementation showed notable improvements. Specifically, we observed higher levels of high-density lipoprotein cholesterol (HDL-C)—often referred to as the "good" cholesterol—and lower triglyceride levels among those treated with vitamin D. Interestingly, the increase in HDL-C and improvement in triglyceride levels underscore vitamin D’s potential role in enhancing lipid profiles in patients struggling with heart disease.
We also noted that vitamin D treatment didn’t significantly impact CRP levels, which are typically used as a marker for inflammation and heart disease risk. This suggests that while vitamin D might help improve certain lipids, its effects on other markers of heart disease need further investigation.
Overall, our study highlights the potential benefits of vitamin D supplementation as a tool to manage heart disease risk factors, offering a promising option for healthcare professionals working with patients suffering from IHD.
Our findings revealed that participants who received vitamin D supplementation showed notable improvements. Specifically, we observed higher levels of high-density lipoprotein cholesterol (HDL-C)—often referred to as the "good" cholesterol—and lower triglyceride levels among those treated with vitamin D. Interestingly, the increase in HDL-C and improvement in triglyceride levels underscore vitamin D’s potential role in enhancing lipid profiles in patients struggling with heart disease.
We also noted that vitamin D treatment didn’t significantly impact CRP levels, which are typically used as a marker for inflammation and heart disease risk. This suggests that while vitamin D might help improve certain lipids, its effects on other markers of heart disease need further investigation.
Overall, our study highlights the potential benefits of vitamin D supplementation as a tool to manage heart disease risk factors, offering a promising option for healthcare professionals working with patients suffering from IHD.
References
- Vanreusel I, Hens W, Van Craenenbroeck EM, Paelinck BP, Segers VFM, et al. Vitamin D levels correlate with exercise capacity in adults with CHD. Cardiol Young. 2025. 10.1017/S1047951125000526
- Fang X, Zhang J, Zhang Z, Ye D. Association between Vitamin D and mortality risk in gout patients. J Public Health (Oxf). 2025. 10.1093/pubmed/fdaf010
- Loh HH, Tay SP, Koa AJ, Yong MC, Said A, et al. Unveiling the benefits of Vitamin D3 with SGLT-2 inhibitors for hypertensive obese obstructive sleep apnea patients. J Transl Med. 2025;23:296. 10.1186/s12967-025-06312-w
- Amer SA, Abo-Elnour DE, Abbas A, Abdelrahman AS, Hamdy HM, et al. Calcium, magnesium, and vitamin D supplementations as complementary therapy for hypertensive patients: a systematic review and meta-analysis. BMC Complement Med Ther. 2025;25:89. 10.1186/s12906-025-04809-x
- Checa-Ros A, Locascio A, Okojie OJ, Abellán-Galiana P, D'Marco L. Perirenal fat differs in patients with chronic kidney disease receiving different vitamin D-based treatments: a preliminary study. BMC Nephrol. 2025;26:119. 10.1186/s12882-025-04041-2
- Liu C, Wongsonegoro H, Sheng T, Fan H, Zhang J. Associations between serum micronutrients and all-cause, cancer, and cardiovascular mortality in a national representative population: Mediated by inflammatory biomarkers. Redox Biol. 2025;81:103573. 10.1016/j.redox.2025.103573
- Zhang N, Wang Y, Li W, Wang Y, Zhang H, et al. Association between serum vitamin D level and cardiovascular disease in Chinese patients with type 2 diabetes mellitus: a cross-sectional study. Sci Rep. 2025;15:6454. 10.1038/s41598-025-90785-8
- Zhang X, Liu J, Han L, Luo G, Jiang P, et al. Vitamin D reduces VSMC foam cell formation and protects against AS progression. J Endocrinol. 2025;265. 10.1530/JOE-24-0056
- Haghighatafshar M, Shekasteband B, Firuzyar T, Etemadi Z, Farhoudi F, et al. The Impact of Vitamin D Deficiency on Coronary Artery Disease Severity Based on Myocardial Perfusion Imaging: A Cross-Sectional Study. Iran J Med Sci. 2025;50:31. 10.30476/ijms.2024.101112.3372
- Bulfone L, Vacca A, Brosolo G, Da Porto A, Bertin N, et al. Subclinical Carotid Disease Is Associated with Low Serum Vitamin D in Nondiabetic Middle-Aged Hypertensive Patients. Nutrients. 2025;17. 10.3390/nu17030480
- Li Q, Tong Y, Guo J, Liang X, Shao H, et al. Vitamin D Receptor Regulates Oxidative Stress and Apoptosis Via the HIF-1α/HO-1 Pathway in Cardiomyocytes. Cell Biochem Biophys. 2025. 10.1007/s12013-025-01681-x
- Astani A, Maroofi A, Hekmatimoghaddam S, Sarebanhassanabadi M, Safari F. Sirtuin 1 mediates the pro-survival effects of vitamin D in angiotensin II-induced hypertrophy of H9c2 cardiomyoblasts. Mol Biol Rep. 2024;52:96. 10.1007/s11033-024-10168-6
- Qi RQ, Chen YF, Cheng J, Song JW, Chen YH, et al. Elabela alleviates cuproptosis and vascular calcification in vitaminD3- overloaded mice via regulation of the PPAR-γ /FDX1 signaling. Mol Med. 2024;30:223. 10.1186/s10020-024-00997-3
- France-Ratcliffe M, Harrison SL, Verma LA, Abdul-Rahim AH, McCallum L, et al. Vitamin D and cardiovascular outcomes in multiple sclerosis. Mult Scler Relat Disord. 2024;92:106155. 10.1016/j.msard.2024.106155
- Sadeghi M, Momeni A, Mirsaeidi FS, Jamalian M, Amirpour A, et al. The Effect of Vitamin D Deficiency Treatment on Lipid Profile and C-reactive Protein in Patients with Ischemic Heart Disease: Double-blind Randomized Clinical Trial. Adv Biomed Res. 2024;13:79. 10.4103/abr.abr_380_23
- Pan YX, Fu YC, Chen H, Zhao MY. [Association of serum 25(OH)D with cardiovascular risk-related indicators: cross-sectional analysis of NHANES]. Zhonghua Yu Fang Yi Xue Za Zhi. 2024;58:1388. 10.3760/cma.j.cn112150-20240519-00403
